stimulation, it works to increase blood flow to the penis and help men to get and maintain an erection. Vardenafil is best taken 1 hour before sexual activity and should only be taken once per day. Doses need to be taken at least 24 hours apart. This is one of the drugs that will have its effects enhanced by grapefruit or grapefruit juice so you want to avoid taking it with those. Vardenafil does not have any other current medical uses.